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In vitro, it appears that a respiratoryrhythm can be generated in very discrete brain-stem regions (Haddad 2003), and the maturationof the putative respiratory centers has been stud-ied extensively (Hilaire and Duron 1999).Nevertheless, discrepancies between the in vitroneural pattern and the natural breathing pattern invivo are common and dif?cult to explain (Achardet al.
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